CanSinoBIO a step closer to becoming 3rd successful shot
Print Edition
CANSINO Biologics Inc’s COVID-19 vaccine showed 65.7 percent efficacy in preventing symptomatic cases and a 90.98 percent success rate in stopping severe disease in an interim analysis of global trials, Pakistan’s health minister said yesterday.
The positive data moves the vaccine, jointly developed by a team led by Chen Wei, a researcher from the Beijing-based Academy of Military Medical Sciences, a step closer to becoming China’s third successful shot for the disease.
The CanSinoBIO vaccine is being tested in Pakistan, Mexico, Russia, Argentina and Chile, according to clinical trial registration data, and the company has supply deals with some of those countries, including Mexico.
Pakistan’s health minister, Faisal Sultan, had said that the country could receive “in the range of tens of millions” of the vaccine under an agreement with the Chinese firm.
Hassan Abbas, head of the CanSinoBIO’s trial at AJ Pharma in Pakistan, said it has already applied to the government for permission to import the vaccine.
“The initial set of vaccines will come in vials already filled, but we hope in the future to get them in the form of concentrates from CanSino, and do the filling here in Pakistan,” he said.
The efficacy of the shot is based on analysis of 30,000 participants and 101 confirmed cases of COVID-19, the minister said on Twitter, quoting data from an independent data monitoring committee.
It was not immediately clear whether the study also looked into the vaccine’s efficacy against new and highly transmissible variants first found in South Africa, Britain and Brazil.
No serious safety concerns have been raised in the study, Sultan said.
In the Pakistani subset, efficacy of the CanSinoBIO vaccine at preventing symptomatic cases was 74.8 percent and 100 percent at preventing severe disease, Sultan added.
CanSinoBIO was not immediately available for comment.
The vaccine, Ad5-nCoV, is also one of the only two one-dose vaccines in the world to release its phase-3 data. The other one-dose vaccine was developed by Johnson & Johnson. The single-shot vaccine can be more effective to execute mass vaccination.
CanSinoBIO’s vaccine, which was approved for use in the Chinese military last year and has since been given to at least 40,000-50,000 people, uses a modified common cold virus known as adenovirus type-5 (Ad5) to carry genetic material from the coronavirus protein into the body.
However, researchers in an early and mid-stage trial report expressed concern the vaccine may not work in those previously exposed to Ad5, as the pre-existing antibody against the common cold virus could weaken the vaccine-triggered immune response.
CanSinoBIO is also testing a two-dose regimen of the vaccine in China including on participants aged between 6 and 17 and older than 55.
Shots from Chinese companies Sinovac and Sinopharm have shown efficacy of between 50 percent and 91 percent.
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